Human melioidosis, infected by the highly pathogenic gram negative bacilli Burkholderia pseudomallei, emerged initially in southeast Asia and northern Australia, and has spread worldwide especially in tropical and subtropical areas ( 1– 3). Septic patients who present with suppurative or undetermined foci and have unsatisfied responses to standard treatment should arouse clinicians to take melioidosis into consideration. Two cases (18.2%) succumbed to infection despite appropriate treatment including targeted antibiotics.Ĭonclusion: Melioidosis has become endemic in central Taiwan. Appropriate empiric and targeted antibiotic treatments were found in 4 (36.4%) and 10 (91.0%) case, respectively. Pneumonitis and extrapulmonary involvement were found in 5 cases (45.4%) each. All cases presented with fever at arrival, but only 4 (36.4%) and 2 (18.2%) cases presented with dyspnea and shock, respectively. Seven (63.6%) cases were diagnosed during 2019–2020, and diabetes mellitus was the most relevant comorbidity (5, 45.4%). Results: Totally 11 melioidosis cases (10 males and 1 female) were diagnosed, among them only 2 (18.2%) cases lived in suburban areas. Methods: The demographic, clinical, laboratory, radiologic, and outcome profiles were collected retrospectively and analyzed from patients whom Burkhoderia pseudomallei was isolated from clinical specimens during the 12-year study period (2011–2022). In this study, we performed the epidemiologic and clinical analyses from the melioidosis cases in central Taiwan.

In Taiwan, most cases are reported in the southern region and no relevant profiles have been reported in central region.

5Division of Infectious Disease, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwanīackground: Melioidosis is a systemic and suppurative disease endemic in the Southeast Asia.

4Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan.

3School of Medicine, Chung Shan Medical University, Taichung, Taiwan.

2Infection Control Center, Chung Shan Medical University Hospital, Taichung, Taiwan.

1Division of Pulmonary Medicine, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.

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